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W329304

Aldrich

 

α-Angelica lactone

≥98%, Kosher, FG

Synonym:4-Hydroxy-3-pentenoic acid γ-lactone, 5-Methyl-2(3H)-furanone
CAS Number:591-12-8
Linear Formula:C5H6O2
Molecular Weight:98.10
FEMA Number:3293
Beilstein Registry Number:108394
EC Number:209-701-8
Council of Europe no.:731
MDL number:MFCD00005375
PubChem Substance ID:24901616
Flavis number:10.012

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Description

Biochem/physiol ActionsPlant-derived cancer chemopreventive agent. Increases the synthesis of glutathione and the activity of glutathione-S-transferase and UDP-glucunonosyltransferase detoxification enzymes in esophagus, stomach, intestine, and liver.
PackagingPackaged in glass bottles
F&F CertificatesGMO Statement
 Food Grade Certificate
 Allergen Statement
 HALAL Statement
 EU Natural Certificate
 US Natural Certificate
 Continuing Guarantee Statement

Properties

gradeFG
 Halal
 Kosher
 NI
assay≥98%
refractive indexn20/D 1.448(lit.)
bp55-56 °C/12 mmHg(lit.)
mp13-17 °C(lit.)
density1.092 g/mL at 25 °C(lit.)
Organolepticoily; nutty

Safety

WGK Germany2
RTECSLU5075000
Flash Point(F)154 °F
Flash Point(C)68 °C

References

referenceNijhoff, W.A., and Peters, W.H., Quantification of induction of rat oesophageal, gastric and pancreatic glutathione and glutathione S-transferases by dietary anticarcinogens. Carcinogenesis 15, 1769-1772, (1994)
 van Lieshout, E.M., et al., Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels. Carcinogenesis 19, 2055-2057, (1998)
 Shepherd, A.G., et al., Regulation of rat glutamate-cysteine ligase (γ-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B1-induced preneoplasia.. Carcinogenesis 21, 1827-1834, (2000)
 Scharf, G., et al., Enhancement of glutathione and γ-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. Nutr. Cancer 45, 74-83, (2003)
 van der Logt, E.M., et al., Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. Carcinogenesis 24, 1651-1656, (2003)
BeilsteinBeil. 17,V,9,120
 Aldrich MSDS 1, 125:B / Arctander, 239 / Corp MSDS 1 (1), 268:C / FT-IR 2 (1), 1188:A / FT-IR 1 (1), 701:C / FT-NMR 1 (1), 1147:B / Fenaroli, 94 / IR-Spectra (3), 409:E / IR-Spectra (2), 362:G / NMR-Reference 2 (1), 594:B / RegBook 1 (1), 813:A / RegBook 39 (1), 813:A / Sax 6, 280 / Structure Index 1, 127:C:4 / Vapor Phase 3, 754:A